Indice de artículos

Nutrición y Alimentación

  1. GA Zavala, OP García, M Camacho  D. Ronquillo, M. Campos-Ponce, C. Doak, K. Polman, JL. Rosado. Intestinal parasites: Associations with intestinal and systemic inflammation. 2018. Parasite Immunology.  40:e12518.  https://doi.org/10.1111/pim.12518
  2. José Guadalupe Gómez Soto,  Tércia Cesária Reis de Souza, Gerardo Mariscal Landina,b, Araceli Aguilera Barreyro, María Guadalupe Bernal Santosa and Konisgmar Escobar García. (2018) Gastrointestinal morphophysiology and presence of kafirins in ileal digesta in growing pigs fed sorghum-based diets. JOURNAL OF APPLIED ANIMAL RESEARCH. VOL. 46, NO. 1, 618–625 https://doi.org/10.1080/09712119.2017.1371607
  3. Nagwa Salih and Elhadi Yahia. 2018. Nutritional value and antioxidant properties of Sudanese underutilized food and eedicinal fruits: Opepe (Sarcocephalus latifolius) and Vitex (Vitex doniana). Food Science and Human Wellness. Submitted.
  4. Villa-Rodriguez, Jose et al, 2018. Major phytochemicals and antiproliferative activity of ‘Hass’ avocado at different ripeness stages. Submitted to Journal of Food Biochemistry.
  5. Anaya-Esparza, Luis Miguel; Dení Ramos-Aguirre; Víctor Manuel Zamora-Gasga; Elhadi Yahia; Efigenia Montalvo-González. 2018. Optimization of ultrasonic-assisted extraction of polyphenol compounds from "Muicle" (Justicia spicigera) leaves. Food Science and Biotechnology. In press.
  6. Ramezanian, Asghar, Sara Atrash, Majid Rahemi, Reza Mostowfizadeh-Ghalamfarsa, and Elhadi Yahia. 2018. Effects of Savory Essential Oil, Gum Arabic and Hot Water on Green Mold Decay in Mexican Limes. HortScience. In press
  7. Villa-Rodriguez, Jose; Idolo Ifie; Elhadi M. Yahia; Alberto Gonzalez-Leon,; Ramon Robles-Zepeda; and Gustavo Adolfo González-Aguilar. 2018. Major phytochemicals and antiproliferative activity of ‘Hass’ avocado at different ripeness stages. Submitted to International Journal of Food Sciences and Nutrition.
  8. Cervantes-Paz, B., J de J Ornelas-Paz, A.A. Gardea-Bejar, E.M. Yahia, C. Rios-Velasco, P.B. Zamadio-Flores, S. Ruiz-Cruz, and V. Ibarra-Junquera. 2018. Compuestos fenolicos de tejote (Crataegus spp) y sus efectos protectors en la salud humana. Revista Fitotecnia Mexicana. In press.
  9. Yahia, Elhadi M., D. Rivera, and J de J Ornelas-Paz. 2018. Bioactive compounds and antioxidant capacity in peels of Opuntia spp and Hylocereus undatus fruits at different ripening stages. Submitted.
  10. Rosas-Domínguez, Cindy, J. Abraham Domínguez Avila, Sunil Pareek, Mónica A. Villegas Ochoa, J. Fernando Ayala Zavala, Elhadi Yahia, Gustavo A. González Aguilar. 2018. Content of bioactive compounds and their contribution to antioxidant capacity during ripening of pineapple (Ananas comosus L.) cv Esmeralda. JABFQ. In Press
  11. Anaya-Esparza, L.M., M.D. Mendez-Robles, A. Perez-Larios, Elhadi M. Yahia, and E. MontalvoGonzalez. 2018. Nutrimental composition and physicochemical parameters of thermosonicated soursop nectar. TIP Revista Especializada en Ciencias Químico Biológicas 21(1): 5-13.
  12. Sagar, N.A., S. Pareek, S. Sharma, E.M. Yahia and M.G. Lobo. 2018. Fruit and vegetable waste: bioactive compounds, extraction and possible utilization. Comprehensive Reviews in Food Science and Food Safety. In press
  13. Babak Madani, Amin Mirshekari, Elhadi Yahia and John B. Golding. 2018. Sapota (Manilkara achras Forb.): Factors Influencing Fresh and Processed Fruit Quality. Horticultural Reviews 45: 105- 142. 
  14. M.Guevara-Cruz, J.M. Vargas-Morales, A.L. Méndez-García, A.M. Lopez-Barradas, O. Granados-Portillo, G. Ordaz-Nava, A.K. Rocha-Viggiano, C.A., Gutierrez-Leyte E. Medna-Cerda, J.L. Rosado, J.C.Morales, N. Torres, AR, Tovar, L.G. Noriega Amino acid profiles of young adults differ by sex, body mass index and insulin resistance; pll S0939-4753 (18) 30015-2, Doi: 10.1016/j.numecd.2018.01.001, Reference NUMECD 1832  revista NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES aceptado 3 enero  2018. 
  15. G. A. Zavala1,2, O. P. García1, M. Camacho1; D. Ronquillo1; M. Campos-Ponce2 ,C. Doak2 ,K. Polman2,3, J. L. Rosado1 Intestinal parasites: Associations with intestinal and systemic inflammation. Parasite Immunol. 2018; https://doi.org/10.1111/pim.12518
  16. M. Guevara-Cruz, J.M Vargas-Morales, A.L Méndez-García, A-M López Barradas, O. Granados-Portillo, G. Ordaz-Nava, A.K Rocha-Viggiano, C.A Gutierrez-Leyte, E. Medina-Cerda, J.L Rosado, J.C Morales, N.Torres, A.R Tovar, L.G Noriega. (2018). Amino acid profiles of young adults differ by sex, body mass index and insulin resistance Nutrition. Metabolism & Cardiovascular Diseases (2017), 1e9. https://doi.org/10.1016/j.numecd.2018.01.001
  17. Miguel A. Duarte – Vazquez, Carlos-Garcia-Ugalde, Laura M, Villegas-Gutierrez, Blanca E. Garcia Almendarez and Jorge L. Rosado. Production of Cow’s Milk Free from Beta-Caseina A1 and Its Application in the Manufacturing of Specialized foods for Early Infant Nutrition. Foods. 2017, 6, 50; doi:10.3390/foods6070050; www.mdpi.com/journal/foods. ISSN
  18. Maria del Carmen Caamaño, Sandra Garcia-Padilla, Miguel Angel Duarte-Vazquez, Karla Elena Gonzalez Romero, Jorge L. Rosado. A Double-Blind, Active-Controlled Clinical Trial of sodium bicarbonate and calcium gluconate in the treatment of bilateral osteoarthritis of the knee., Clinical Medicine Insights:  Arthritis and Musculoskaletal Disorders. Doi: 10.1177/1179544116688899 publicado 2017
  19. Zavala GA, Rosado JL, Doak CM, Del Carmen Caamaño M, Campos-Ponce M, Ronquillo D, Polman K Garcia OP. Energy and food intake are associated specific intestinal parasitic infections in children of rural Mexico. Aceptado Parasitol International doi: 10.1016/j.parint.2017.07.005
  20. José Guadalupe Gómez Soto, Tércia Cesária Reis de Souza, Gerardo Mariscal Landin, Araceli Aguilera Barreyro, María Guadalupe Bernal Santos & Konisgmar Escobar García. Gastrointestinal morphophysiology and presence of kafirins in ileal digesta in growing pigs fed sorghum-based diets. JOURNAL OF APPLIED ANIMAL RESEARCH, 2017. Pp. 1-8.
  21. Marina Banuet-Martínez, Wendy Espinosa-de Aquino, Fernando R. Elorriaga Verplancken, Adriana Flores-Morán,  Olga P. García,  Mariela Camacho Karina Acevedo Whitehouse. Climatic anomaly affects the immune competence of California sea lions. 2017. PLoS ONE 12(6): e0179359.
  22. Gerardo A. Zavala, Jorge L. Rosado, Colleen M. Doak, Maria del Carmen Caamaño, Maiza Campos-Ponce, Dolores Ronquillo, Katja Polman, Olga P. García. 2017. Energy and food intake are associated specific intestinal parasitic infections in children of rural Mexico. Parasitology International. doi: 10.1016/j.parint.2017.07.005
  23.  Banuet-Martínez M, Espinosa-de Aquino W, Elorriaga-Verplancken FR, Flores-Moran A, García OP, Camacho M, Acevedo-Whitehouse K. (2017). Climatic anomaly effects the inmune competence of California sea lions. PLoS One 12(6): e0179359.   https://doi.org/10.1371/journal.pone.0179359
  24. T.C. Reis de Souza1, K. Escobar1, G. A. Aguilera1, B. E. Ramírez2, R. G. Mariscal-Landín. Sesame meal as the first protein source in piglet starter diets and advantages of a phytase: a digestive study. South African Journal of Animal Science 2017, 47 (No. 5). http://dx.doi.org/10.4314/sajas.v47i5.3
  25. Gerardo Mariscal-Landín, Tércia Cesária Reis de Souza and Alejandro Bayardo Uribe. Neutral detergent fiber increases endogenous ileal losses but has no effect on ileal digestibility of amino acids in growing pigs. Animal Science Journal (2017) 88, 322–330. doi:10.1111/asj.12633Animal
  26. Julia María Alatorre-Cruz, Wendoline Pita-López, Rosa Guadalupe López-Reyes, Roberto Augusto Ferríz-Martínez, Ricardo Cervantes-Jiménez, María de Jesús Guerrero Carrillo, Paola Jazmín Aranda Vargas, Gabriela López-Herrera, Adriana Jheny Rodríguez-Méndez, Aarón Zamora-Arroyo, Héctor Gutiérrez-Sánchez,  Tércia Reis de Souza, Alejandro Blanco-Labra, Teresa García-Gasca. (2017). Effects of intragastrically-administered Tepary bean lectins on digestive and immune organs: Preclinical evaluation. Toxicology reports 5. https://doi.org/10.1016/j.toxrep.2017.12.008
  27. Areli E.Torres-Bojórquez1, Oscar R. García-Rubio1, Rita Miranda-López2, Anaberta Cardador-Martínez3 (2017) Evaluación de la capacidad antioxidante, características fisicoquímicas y perfil sensorial de Opuntia robusta y O. ficus-indica. Archivos Latinoamericanos de Nutrición. Vol. 67 No. 4
  28. Cervantes-Paz, B.; J.J. Ornelas-Paz, S. Ruiz-Cruz; C. Rios-Velasco; V. Ibarra-Junquera; E. M. Yahia; and A. A. Gardea-Béjar. 2017. Effects of pectin on lipid digestion and possible implications for carotenoid bioavailability during pre-absorptive stages: A review. Food Research International 99(Pt 2): 917-927.
  29. M. Guevara-Cruz, J.M Vargas-Morales, A.L Méndez-García, A-M López Barradas, O. Granados-Portillo, G. Ordaz-Nava, A.K Rocha-Viggiano, C.A Gutierrez-Leyte, E. Medina-Cerda, J.L Rosado, J.C Morales, N.Torres, A.R Tovar, L.G Noriega. (2018). Amino acid profiles of young adults differ by sex, body mass index and insulin resistanceNutrition. Metabolism & Cardiovascular Diseases (2017) xx, 1e9. https://doi.org/10.1016/j.numecd.2018.01.001
  30. Jorge L. Rosado. 2016. Intolerancia a la lactosa. Gaceta Médica de México. 2016;152 Suppl 1
  31. Caamaño MC, Ronquillo D, Kimoto R, García OP, Long KZ, Rosado JL. Beliefs and motives related to eating and body size: a comparison of high-BMI and normal-weight young adult women from rural and urban areas in Mexico. DOI 10.1186/s12889-016-3695-4. BMC Public Health. 2016 Sep 26;16(1):1014.
  32. García-Solís P, Reyes-Bastidas M, Flores K, García OP, Rosado JL, Méndez-Villa L, Garcia-G C, García-Gutiérrez D, Kuri-García A, Hernández-Montiel HL, Soriano-Leon O, Villagrán-Herrera ME, Solis-Sainz JC Fat mass obesity-associated (FTO) (rs9939609) and melanocortin 4 receptor (MC4R) (rs17782313) SNP are positively associated with obesity and blood pressure in Mexican school-aged children. Br J Nutr. 2016 Nov 10:1-7.
  33. Torres-Sánchez L, López-Carrillo L, rosado jl,  rodriguez vm, vera-aguilar e, kordas k,  garcía-vargas gg, cebrian me. Sex differences in the reduction of arsenic methylation capacity as a function of urinary total and inorganic arsenic in mexican children. Environ Res 2016 Nov 21;151:38-43. Epub 2016 Dec 21.
  34. Duarte-Vázquez Miguel Ángel, Gómez-Solís María Antonieta, Gómez-Cansino Rocio, Reyes-Esparza Jorge, Jorge Luis Rosado, and Rodríguez-Fragoso lourdes* Effects of combined resveratrol plus metformin therapy in db/db diabetic Mice; Journal of Metabolic Syndrome. Doi:10.4172/2167-0943.1000217, vol. 5 Issue 4 1000217, pag.1/7 ISSN 2167-0943.  P.13 /12/2016
  35. Katarzyna Kordas, Aditi Roy, Patricia López, Gonzalo García-Vargas, Mariano E. Cebrián, Eunice Vera-Aguilar, and Jorge L. Rosado ”Iron and Zinc Supplementation Does Not Impact Urinary Arsenic Excretion in Mexican School Children”, THE JOURNAL OF PEDIATRICS • www.jpeds.com, 0022-3476/ Elsevier Inc. All rights reserved http://dx.doi.org10.1016/j.jpeds.2017.02.040
  36. Corrales-Bernal1, Andrea, Gabriela Jaramillo, Berardo Rodríguez, Elhadi M. Yahia, and Maria Elena Maldonado-Celis. 2016.  Mango (Mangifera indica cv. Azúcar) antiinflammatory and chemopreventive role during colorectal carcinogenesis. Emirates Journal of Food and Agriculture. 2016. 28(10): 704-712. 
  37. González EM, Fernández AEL, Sáyago-Ayerdi SG, Estrada RMV, Vallejo LGZ, and Yahia, EM. 2016. In Vitro Antioxidant Capacity of Crude Extracts and Acetogenin Fraction of Soursop Fruit Pulp. Pharm Anal Acta 7: 484. doi:10.4172/2153-2435.1000484.
  38. Coria-Téllez, Ana V.; Elhadi M. Yahia; Efigenia Montalvo-Gónzalez; and Eva N. Obledo-Vázquez. 2016. Annona muricata: Phytochemicals, pharmacological and tradicional medicine uses, and toxicity. A Review. Arabian Journal of Chemistry. In press.
  39. Rosado JL, Lactose Intolerance, Gaceta. Med. Mex. 2016;152 Suppl 1:67-73. 
  40. García OP, Martínez M, Romano D, Camacho M, de Moura FF, Abrams SA, Khanna HK, Dale JL, Rosado JL. Iron absorption in raw and cooked bananas: a field study using stable isotopes in women (2015). Food Nutr Res 59:25976
  41. Velazquez Vázquez C, Villa Rojas G, Alvarez Ramírez C, Chávez-Servín JL, García-Gasca T, Ferriz Martínez RA, García OP, Rosado JL, López-Sabater CC, Castello AI, Andrade Montemayor HM, de la Torre Carbot K. Total Phenolic Compounds in Milk from Different Species. Design of an Extraction Technique for Quantification Using the Folin-Ciocalteau Method. (2015) Food Chem 176:480-486
  42. Caamaño MC, Gutiérrez J, García OP, Ronquillo D, Martínez G, Rosado JL. Increased calorie intake at a specific mid-morning meal and increased intake of soft-drinks are strongly associated with obesity in Mexican rural women. (2015) Ecol Food Nutr. 176:480-6.
  43. Aguilera Barreyro A, Reis de Souza T, Mariscal-Landín G, Guerrero Carrillo MJ, Escobar García K, Bernal Santos G, García Gasca T. (2014). Morphophysiological adaptations of the gastrointestinal tract in piglets fed a sesame meal or soybean meal diet. American Journal of Animal and Veterinary Sciences 9(1): 28-35
  44. Kimoto R, Ronquillo D, Caamaño MC, Martínez G, Schubert L, Rosado JL, García OP, Long KZ. Food, eating and body image in the lives of low socioeconomic status Mexican women living in a rural obesogenic environment (2014). Health Place 2014;25:34-42.
  45. Méndez-Villa L, Elton-Puente JE, Solis JC, Sampson-Zaldívar E, García-G C, Villalobos P, Colarossi A, García OP, Robles-Osorio L, García-Solis P. Iodine Nutrition and Thyroid Function Assessment in Childbearing Age Women from Queretaro, Mexico (2014) Nutr Hosp 29(1):204-211.
  46. García OP, Ronquillo D, Caamaño MC, Martínez M, Camacho M, López V, Rosado JL. Zinc, iron, vitamins A, C and E are associated with obesity, inflammation, lipid profile, and insulin resistance in Mexican school-age children (2013). Nutrients 5:5012-5030
  47. Reyes-Esparza J, Mendoza-Rivera B, De la Cruz-Cordero R, Rosado JL, Duarte-Vázquez MÁ, Solis MG, Vite-Vallejo O, Rodríguez-Fragoso L. (2013) Pharmacological evaluation of a β-hydroxyphosphonate analogue of l-carnitine in obese Zucker fa/fa rats. Basic Clin Pharmacol Toxicol, 112: 222-228.
  48. Victoria-Campos CI, Ornelas-Paz JD, Yahia EM, Jiménez-Castro JA, Cervantes-Paz B, Ibarra-Junquera V, Pérez-Martínez JD, Zamudio-Flores PB, Escalante-Minakata MD (2013) Effect of Ripening, Heat Processing, and Fat Type on the Micellarization of Pigments from Jalapeño Peppers. J Agric Food Chem. [Epub]
  49. Ornelas-Paz DJ, Yahia EM. (2013) Effect of the moisture content of the forced hot air on the postharvest quality and bioactive compounds of mango fruit (Mangifera indica L. Cv. Manila). J Sci Food Agric. doi: 10.1002/jsfa.6384. [Epub].
  50. Victoria-Campos CI, Ornelas-Paz JD, Yahia EM, Failla ML. Effect of the interaction of heat-processing style and fat type on the micellarization of lipid-soluble pigments from green and red pungent peppers (Capsicum annuum). (2013) J Agric Food Chem, 61:3642-3653.
  51. Ornelas-Paz DJ, Yahia EM, Ramírez-Bustamante N, Pérez-Martínez JD, Escalante-Minakata Mdel P, Ibarra-Junquera V, Acosta-Muñiz C, Guerrero-Prieto V, Ochoa-Reyes E. (2013) Physical attributes and chemical composition of organic strawberry fruit (Fragaria x ananassa Duch, Cv. Albion) at six stages of ripening. Food Chem, 138:372-381.
  52. Emanuel MA, Gutierrez-Orozco F, Yahia EM, Benkeblia N. (2013) Assessment and profiling of the fatty acids in two ackee fruit (Blighia sapida Köenig) varieties during different ripening stages. J Sci Food Agric, 93:722-726.
  53. Rosado JL, Díaz M, Muñoz E, Westcott JL, González KE, Krebs NF, Caamaño MC, Hambidge M. (2012). Bioavailability of zinc oxide added to corn tortilla is similar to that of zinc sulfate and is not affected by simultaneous addition of iron. Food Nutr Bull, 33:261-266.
  54. Shahab-Ferdows S, Anaya-Loyola MA, Vergara-Castañeda H, Rosado JL, Keyes WR, Newman JW, Miller JW, Allen LH. (2012) Vitamin B-12 supplementation of rural Mexican women changes biochemical vitamin B-12 status indicators but does not affect hematology or a bone turnover marker. J Nutr, 142: 1881-1887.
  55. García OP, Ronquillo D, Caamaño MC, Camacho M, Long KZ, Rosado JL. (2012) Zinc, vitamin A, and vitamin C status are associated with leptin concentrations and obesity in Mexican women: results from a cross-sectional study. Nutr Metab (Lond),15: 59.
  56. Zavala G, Long KZ, García OP, Caamaño MD, Aguilar T, Salgado LM, Rosado JL. (2012) Specific micronutrient concentrations are associated with inflammatory cytokines in a rural population of Mexican women with a high prevalence of obesity. Br J Nutr, 29:1-9.
  57. Tovar AR, Caamaño MC, Garcia-Padilla S, García OP, Duarte MA, Rosado JL. (2012) The inclusion of a partial meal replacement with or without inulin to a calorie restricted diet contributes to reach recommended intakes of micronutrients and decrease plasma triglycerides: a randomized clinical trial in obese Mexican women. Nutr J, 11: 44
  58. García OP. (2012) Effect of vitamin A deficiency on the immune response in obesity. Proc Nutr Soc,71: 290-297.
  59. Aguirre C, Torres I, Mendoza-Hernández G, Garcia-Gasca T, Blanco-Labra A. (2012) Analysis of protein fractions and some minerals present in chan (Hyptis suaveolens L.) seeds. J Food Sci. 77(1):C15-9.
  60. Cervantes-Paz B, Yahia EM, Ornelas-Paz DJ, Gardea-Béjar AA, Ibarra-Junquera V, Pérez-Martínez JD. (2012) Effect of heat processing on the profile of pigments and antioxidant capacity of green and red jalapeño peppers. J Agric Food Chem, 60:10822-10833.
  61. Palafox-Carlos H, Yahia E, Islas-Osuna MA, Gutierrez-Martinez P, Robles-Sánchez MGonzález-Aguilar GA (2012) Effect of ripeness stage of mango fruit (Mangifera indica L., cv. Ataulfo) on physiological parameters and antioxidant activity. Scientia Horticulturae 135: 7-13.
  62. Rosado JL, Garcia OP, Ronquillo D, Hervert-Hernández D, Caamaño MC, Martínez G, Gutiérrez J, García S. (2011) Intake of milk with added micronutrients increases the effectiveness of an energy-restricted diet to reduce body weight: a randomized controlled clinical trial in Mexican women. J Am Diet Assoc, 111: 1507-1516.
  63. Rubio-Andrade M, Valdés-Pérezgasga F, Alonso J, Rosado JL, Cebrián ME, García-Vargas GG. (2011) Follow-up study on lead exposure in children living in a smelter community in northern Mexico. Environ Health,10: 66.
  64. Roy A, Kordas K, Lopez P, Rosado JL, Cebrian ME, Vargas GG, Ronquillo D, Stoltzfus RJ. (2011) Association between arsenic exposure and behavior among first-graders from Torreón, Mexico. Environ Res, 111: 670-676.
  65. Long KZ, Garcia C, Ko G, Santos JI, Al Mamun A, Rosado JL, DuPont HL, Nathakumar N. (2011) Vitamin A modifies the intestinal chemokine and cytokine responses to norovirus infection in Mexican children. J Nutr, 141: 957-963.
  66. Rosado JL, López P, García OP, Alatorre J, Alvarado C. (2011) Effectiveness of the nutritional supplement used in the Mexican Oportunidades programme on growth, anaemia, morbidity and cognitive development in children aged 12-24 months. Public Health Nutr, 14: 931-937.
  67. Long KZ, Santos JI, Rosado JL, Estrada-Garcia T, Haas M, Al Mamun A, DuPont HL, Nanthakumar NN. (2011) Vitamin A supplementation modifies the association between mucosal innate and adaptive immune responses and resolution of enteric pathogen infections. Am J Clin Nutr, 93: 578-585.
  68. Castañer O, Fitó M, López-Sabater MC, Poulsen HE, Nyyssönen K, Schröder H, Salonen JT, De la Torre-Carbot K, Zunft HF, De la Torre R, Bäumler H, Gaddi AV, Saez GT, Tomás M, Covas MI; EUROLIVE Study Group (2011). The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial. Clinical Nutrition 30(4):490-493.
  69. Cruz-Bravo RK, Guevara-Gonzalez R, Ramos-Gomez M, Garcia-Gasca T, Campos-Vega R, Oomah BD, Loarca-Piña G. (2011). Fermented nondigestible fraction from common bean (Phaseolus vulgaris L.) cultivar Negro 8025 modulates HT-29 cell behavior. J Food Sci. 76(2):T41-47.
  70. Andrade-Montemayor, H., A. V. Córdova-Torres; T. García-García; R. J. Kawas (2011). Alternative foods for small ruminants in semiarid zone, the case of mesquite (Prosopis laevigata) and nopal (Opuntia spp.). Small ruminant research 98: 83-92.
  71. Foote, M.R., S.L. Giesy, G. Bernal-Santos, D.E. Bauman and Y.R. Boisclair. (2011) t10,c12-CLA decreases adiposity in peripubertal mice without dose-related detrimental effects on mammary development, inflammation status and metabolism. J. of Physiol. 299: 1521-1528